At the airport take a taxi to Chamartin Train Station (be careful because there are two train stations in Madrid and the only one that has trains to Salamanca is the Chamartin station). The taxi ride will take a half an hour and should be between 25€ and 30 € (depending on your luggage).

Then take the train to Salamanca. There are 6 departures from Madrid/Chamartin to Salamanca daily and the train ride will take two and a half hours. The train departure times are as follows:

Orientative prices: One Way ticket: 14.15 Euros Return ticket: 25.50 Euros

Alternatively, you could take the metro from the airport to Chamartin train station. It costs 1 Euro and takes about 30 minutes. You will have to change lines at 'Nuevos Ministerios'.

After you arrive at the Barajas Airport, take a taxi from the airport to 'Sur - Mendez Alvaro Bus Station' or the "Auto-res Bus Station." The taxi ride will last approximately a half an hour and should be between 25 and 30 € depending on how much luggage you have.

At the bus station, take an express bus to Salamanca, you have one every hour: From 07.00 to 22.00 hours (Monday to Satudary) From 08.00 to 23.00 hours (Sunday)

Orientative prices: One Way ticket 16 € Return ticket 26

Alternatively, you could take the metro from the airport to the metro stop 'Plaza Sur - Mendez Alvaro'. The metro costs 1 Euro and it will take you about 40 minutes. You will have to change lines at the metro stop 'Nuevos Ministerios'.